7-substituted 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3- quinolinecarboxylic acids: synthesis and biological activity of a new class of quinolone antibacterials

J Med Chem. 1988 Mar;31(3):503-6. doi: 10.1021/jm00398a003.

Authors

J M Domagala¹, S E Hagen, C L Heifetz, M P Hutt, T F Mich, J P Sanchez, A K Trehan

Affiliation

¹ Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan 48105.

PMID: 3346869
DOI: 10.1021/jm00398a003

No abstract available

MeSH terms

Anti-Bacterial Agents / chemical synthesis*
Chemical Phenomena
Chemistry
Ciprofloxacin / pharmacology
Gram-Negative Bacteria / drug effects
Microbial Sensitivity Tests
Quinolines / chemical synthesis*
Quinolines / pharmacology
Structure-Activity Relationship

Substances

Anti-Bacterial Agents
Quinolines
Ciprofloxacin